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A founder population of 1,000 wouldn't be unprecendented.

https://en.wikipedia.org/wiki/Population_bottleneck#Humans

The real problem is that an individual can only learn so much and 1,000 can't support the skills needed to run something like a modern civilization.



The first and possibly only settlers will be AIs.

The scientific breakthroughs needed to make an interstellar spaceship are so far away that we must assume they'll be post-singularity tech.




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