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Thank you, @GordonS! I will go read up about β-arrestin.

If it is scheduled, does that increase the chance of a safe(r) opioid replacement being developed?

And can you kindly point me to some text books/journals or introductory chemistry in order to understand these interactions at a fundamental level?



Here are a few DOIs to look up on sci-hub:

- 10.1093/bja/aer29

- 10.1007/978-3-642-41199-1_22

- 10.1213/01.ANE.0000160588.32007.AD

- 10.1124/mol.106.028258

- 10.1124/jpet.105.087254

- 10.1523/JNEUROSCI.5999-10.2011

I should add that I'm not a chemist, I just have a keen, self-vested interest in analgesic substances.




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