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> Edited to add that I quit tobacco ~7 years ago using chantix, which I totally recommend. Unfortunately my mental ilnesses have become harder to deal with over the same period.

I learned from someone here (about 4 months ago [1]) that nicotine is not so addictive by itself. It is the combination of MAOI-like chemicals in tobacco that makes it hard for smokers to quit. MAOI's were the "first generation" anti-depressants. They were reasonably effective, but caused high blood pressure when combined with fine aged cheese.

[1] https://news.ycombinator.com/item?id=12527585

No new drugs are needed to help "schizophrenics", the industry just needs to implement what's already known. For example, niacinamide [2] is a form of Vitamin B-3 that many people find helps reduce their need for tobacco. It is structurally similar to nicotine.

[2] https://purebulk.com/niacinamide-powder/



>but caused high blood pressure when combined with fine aged cheese.

Are you serious about this?


It's true. If the MAO-I acts on both MAO-A and MAO-B, that is it is non-selective, then the tyramine in the cheese can cause a hypertensive crisis:

https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor#Hy...

Edit: spelling


People taking MAOIs need to follow a careful diet to avoid many types of food.

http://www.gloshospitals.nhs.uk/SharePoint110/Antibiotics%20...




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