Having a root process with write-privileges to /etc on production machines and also able to communicate over the Internet definitely is a security risk.
To mitigate that you end-up building a series of privilege-restricted jobs flowing from the DMZ back into the internal network. And maintaining that might be more complicated than just manually renewing, depending upon the processes and architecture of the company.
Most popular ACME (Let's Encrypt) clients allow you to provide a CSR instead of generating the keys themselves. That means a bunch more work for you, but if you're worried about this, that's what you should do. Have your safe (even manual if you insist) process make keys, make CSRs for the keys, and put those somewhere readable. The ACME client will hand them over to the CA saying "I want certs corresponding to these CSRs" without needing access to your TLS private keys at all.
This is technically true, but contextually lacking.
acme-go/lego doesn't use HTTP validation unless you disable just about every other form of validation first. TLS-ALPN validation is much more likely, so port 443.
That said, it is very easy to allow software to bind to privileged ports without providing it root access; this has been solved for a very, very long time.