Yes, if it's not componentized into a smaller chunk, find and replace works fine. The beauty of Tailwind is though, if you change that, you know exactly what the consequence is since every utility is so highly targeted.
You absolutely do skip between lots of HTML/JSX/VUE files, but that's true of any project. The point of tailwind is to keep you in the view layer of your project and not jumping between more than a browser and one tab in a code editor when building your UI.
In my experience global replace is much easier across multiple component files rather than multiple CSS files. If I need to do change a font color I do a search and know to change it based on the file/component it's used in. If I had to change the color in css files I'd have to review the class and also track down where that class is in use.
You absolutely do skip between lots of HTML/JSX/VUE files, but that's true of any project. The point of tailwind is to keep you in the view layer of your project and not jumping between more than a browser and one tab in a code editor when building your UI.