What type of connection do these system have (e.g. 10GbE) and how much latency? Would it be possible to span a ZFS Pool across multiple regions (us, europe, ...)?
The two systems are in different buildings on campus. Each system (with 140) drives is a single unit, with 60-drive JBODs running on SAS-external connections.
If you want to span a pool across multiple regions, you'll want a distributed file system on top of your ZFS to manage that. Something like Lustre or Ceph. It would still be very challenging, though.