David Baker's group (author of the RoseTTAFold paper out today in science) has multiple exciting examples of de novo design of proteins.

For example, see [1] or [2], and [2] was spun off into a company (Neoleukin Therapeutics).

[1] https://science.sciencemag.org/content/371/6531/eabc8182 [2] https://www.nature.com/articles/s41586-018-0830-7