I got curious. If you put 1 picogram into Einstein's equation, you get about 90 joules of energy on annihilation. That's a bit more than half the energy delivered by a 90mph baseball or about half the energy of a defibrillator pulse.

Or wait, do you double it since you're annihilating a picogram of matter and antimatter?

Either way, that's a bonkers amount of energy from picograms of mass.