Everything except us-east-1 is generally pretty reliable. At $work we have a lot of stuff that's only on eu-west-1 (yes not the best practice) and we haven't had any issues, touch wood
My impression is that `us-east-1` has the worst reliability track record of any region. We've always run our stuff in `us-west-2` and there has never been an outage that took us down in that region. By contrast, a few things that we had in `us-east-1` have gone down repeatedly.
It’s the “original” AWS region. It has the most legacy baggage, the most customer demand (at least in the USA), and it’s also the region that hosts the management layer of most “global” services. Its availability has also been dogshit, but because companies only care about costs today and not harms tomorrow, they usually hire or contract out to talent that similarly only cares about the bottom line today and throws stuff into us-east-1 rather than figure out AZs and regions.
The best advice I can give to any org in AWS is to get out of us-east-1. If you use a service whose management layer is based there, make sure you have break-glass processes in place or, better yet, diversify to other services entirely to reduce/eliminate single points of failure.
Former AWS employee here. There's a number of reasons but it mostly boils down to:
It's both the oldest and largest (most ec2 hosts, most objects in s3, etc) AWS region, and due to those things it's the region most likely to encounter an edge case in prod.
