Yes, I daily drive Qubes. It's an amazing feeling to feel in full control over your computing and not being afraid to open any links or attachments. Here is my Qubes OS Elevator Pitch: https://forum.qubes-os.org/t/how-to-pitch-qubes-os/4499/15

It's slow for tasks requiring GPU, but allowing GPU for chosen, trusted VMs is planned: https://github.com/QubesOS/qubes-issues/issues/8552