I think a standard laptop is pretty much the most ergonomic possible layout. The too-big keyboard is one bad thing about the standard layout and the mouse on the side is the other.
My wrists disagree vigorously with you, sir, on that. Standard laptops have terrible ergonomics not only related to key spacing issues (frequently too tight) but also the abruptness with which the keys stop (being as it is almost entirely rigid instead of the progressive resistance a good, say, Model M has).
