No personal experience, but I can't imagine thinking less of someone for taking work with a candidate, even if I didn't personally like the candidate – it'd at least make you stand out a little more. Plus, if there were a hiring manager who would hold it against you that you worked for Hillary Clinton or Mitt Romney or John McCain or whomever, that's probably a manager who's unbearable in other ways too.

One potential (and, again, totally made-up) caveat: Working for a well-known politician like Hillary Clinton is probably very different from working with a joke candidate or the "Rent is too damn high" guy.

A very liberal friend applied to the Romney campaign during the previous election cycle and ended up working on his campaign. Didn't hurt his career at all, and he got a lot of good stories out of it.